Effect Of Alcoholic Extract Of Brassica Oleracea L. Var. Capitata Plant Leaves On Glucose Level And Antioxidant Activity In Alloxaninduced Diabetic Rats

Abstract

Objective: The aim of this study was to investigate the effect of ethanolic extract of Brassica
oleracea var. Capitata (Cabbage) Plant Leaves of Glucose Level and Antioxidant Activity in
Alloxan-Induced Diabetic Rats.
Methods: Thirty mature male rats were used in five groups, the first group kept as a normal
group. The second group (Diabetic group) received a single dose of alloxan (150 mg/kg BW
i.p.) to induction of Diabetes mellitus type 2 (T2DM) while the third, fourth, and fifth groups
were diabetic rats received 150, 300, 600 mg/kg, respectively, of Brassica oleracea var.
capitata ethanolic extracts orally for 60 days after induction of T2DM. Body weights were
recorded after and before treatment. Animals were sacrified after 24 h of the last dose and
heart blood samples were collected for biochemical study.
Results: The presence of a significant decrease (P less than 0.05) in the body weights and reduced
Glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase1 (GPX1) levels
and significant increase (P less than 0.05) in the Fasting plasma Glucose (FPG) and malondialdehyde
(MDA) levels in the diabetic group compared with normal group. In contrast, it was noted the
presence of significant increase (P less than 0.05) in the body weights and GSH, SOD and GPX1 levels
and significant decrease (P less than 0.05) in the FPG and MDA levels in diabetic rats that treated with
300, 600 mg/kg BW of extract as compared with diabetic group rats.
Conclusion: The present study ascertains that the Ethanolic extracts of Brassica oleracea var.
Capitata Plant Leaves possesses antihyperglycemic and antioxidant properties.